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The Most Advanced Proteolytic + Full-Spectrum Enzyme Supplement on the Market

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  • P3E uses cultured enzymes which can be 100 to 1000 times more powerful than food enzymes
  • Tri-phase protease works at every stomach pH level so all the protein you eat is broken down into usable building blocks
  • Boosts energy by increasing metabolism of carbs, fat, and protein for fuel
  • Improves digestive balance and reduces acid reflux, constipation, gas, and bloating
  • Increases absorption of certain vitamins and minerals
  • Helps repair damaged intestinal walls where most nutrient absorption problems occur


  • Serving Size: 3 capsules
  • # of Servings: 40
  • Form: Powder in plant cellulose capsules
  • Capsule Size: Standard size 0 (7.5mm x 21mm)


  • Take 3 capsules with every meal
  • If desired, capsules can be opened and powder added to water or any beverage


Your digestive system is ground zero for your health. But as you age, it starts losing the ability to properly break down food. The result? Your body can become depleted in nutrients and at risk for chronic conditions. Digestive enzymes are the powerful compounds that help your digestive system extract the vitamins, minerals, and amino acids your body needs to maintain life. They’re also essential for keeping your immune system strong. Unfortunately, aging and a poor diet rapidly diminish your body’s natural enzyme stores.

Organixx P3E® is one of the most cutting-edge and powerful digestive enzyme formulas available. It contains the expensive and difficult-to-produce protease, amylase, and lipase that most other enzyme supplements lack. P3E is scientifically designed to help your body thrive by deriving the absolute most nutritional value from the foods you eat.


Tri-Phase Proteolytic Protease Enzymes <span class="highlight">(Breaks Down Proteins, Reduces Acid Reflux &amp; Bloating)</span>

Tri-Phase Proteolytic Protease Enzymes (Breaks Down Proteins, Reduces Acid Reflux & Bloating)

Also known as proteolytic enzymes, proteases are responsible for breaking down the proteins and peptides in food into amino acids – the building blocks of the body used for making and maintaining muscle tissue and organs. But what makes proteases extra special is that they have the ability to act as both digestive enzymes and systemic enzymes. Not only do proteases support optimal digestion, but they’re important for circulatory health, cell division, apoptosis (programmed cell death), and more.4

When taken on an empty stomach, proteases can bypass the stomach and enter the bloodstream directly, where they help to break down excess fibrin. Fibrin is an insoluble protein compound that the body naturally uses to heal injuries by forming scar tissue.5, 6 Too much fibrin in the blood, however, can increase blood pressure and inhibit the healing process by creating inflammation, growths, and adhesions that lead to increased pain, chronic fatigue, and a higher risk of heart attack and stroke.7

Research has shown that proteolytic enzymes can also help to reduce pain, swelling, and bruising after surgery,8 aid with delayed-onset muscle soreness after exercise,9 and help with managing pain in patients with inflammatory conditions.10 They are also increasingly being used in cancer treatment and management.11

When taken with meals, proteases act as digestive enzymes that help ensure the protein in your food is fully digested for maximum nutrient absorption. The benefits of improved digestion range from reduced bloating, acid reflux, belching, and flatulence, to increased energy and easier weight management.

In supplements, you’ll often see proteases labeled using a number scale based on their activity in various pH environments, typically ranging from 3.0-6.0. The higher the protease number, the broader its spectrum of activity within the digestive tract.

Over 55% of Organixx Enzyme 17 is comprised of 5 kinds of protease enzymes in a tri-phase proteolytic enzyme formula. This means the enzymes are able to function in three distinct pH levels in the digestive tract to break down virtually any protein from plant and animal sources:

Protease 3.0 is characterized by its ability to hydrolyze (break down) proteins under acid conditions in the stomach. 

Protease 4.5 works to provide protein digestion in the stomach and pyloric regions of the small intestine.

Protease 6.0 works with other enzymes to provide protein digestion throughout the digestive tract.

Digestive Enzyme Blend <span class="highlight">(Breaks Down Carbohydrates, Fats, &amp; Proteins)</span>

Digestive Enzyme Blend (Breaks Down Carbohydrates, Fats, & Proteins)

Enzyme 17 offers a proprietary full-spectrum blend of 13 different digestive enzymes designed to enhance digestion for ALL types of foods and dietary styles. Digestive enzymes help to pre-digest food before it passes into the stomach and small intestine, mimicking the enzymes naturally produced by the pancreas.12 Only when food is broken down (i.e., digested) can nutrients be extracted and utilized by the body.

There are many diverse kinds of digestive enzymes which are needed for digesting different kinds of foods. For example, people who can’t digest dairy products (a condition known as lactose intolerance) can find relief by supplementing with the enzyme lactase.13 People who get gassy when eating beans and cruciferous vegetables can benefit by supplementing with the enzyme alpha galactosidase. Most people eat a broad range of foods that include different types of carbohydrates, fats, and proteins, and will benefit from a full-spectrum digestive enzyme supplement.

The full-spectrum digestive enzyme blend in Enzyme 17 includes:

Amylase to break down carbohydrates, sugars, and starches in grains, rice, potatoes, fruits, vegetables, beans, and herbs.

Alpha Galactosidase to break down simple sugars (polysaccharides) and complex sugars (oligosaccharides) in legumes and cruciferous vegetables.

Beta-glucanase to breaks down cellulose (plant fiber) in grains and cereals.

Bromelain to break down proteins, and also provides proteolytic (systemic) support for the body.

Cellulase to break down food fiber (cellulose) in fruits and vegetables.

Diastase maltase to break down carbohydrate-rich foods into other types of sugar that can be more easily used by the body.

Glucoamylase to break down long-chain carbohydrates and starches in foods such as grains and potatoes.

Hemicellulase to break down hemicellulose, a type of cellulose in plant walls, as well as non-cellulose polysaccharides.

Invertase to break down sucrose and simple sugars.

Lactase to break down lactose, a simple sugar found in milk and dairy products.

Lipase to break down fats in butter, cheese, meat, and oils.

Pectinase to break down pectin, a polysaccharide found in fruits and vegetables.

Phytase to break down carbohydrates, as well as “anti-nutrients” like phytic acid in plants, grains, and seeds.

Enzyme 17 also uses cultured enzymes that have been extracted from a fermentation process and offer the benefit of being anywhere from 100 to 1000 times more powerful than a typical food enzyme. The culturing process is very time consuming and expensive, which is why so few digestive enzyme supplements on the market contain cultured enzymes.

Your body can’t digest food properly when it’s lacking in digestive enzymes. By supplying your body with the enzymes it needs, you’ll facilitate nutrient absorption (for better energy and overall health) while helping to relieve the painful symptoms of poor digestion.

AstraZyme® <span class="highlight">(Increases Nutrient Absorption by Up to 66%)</span>

AstraZyme® (Increases Nutrient Absorption by Up to 66%)

A proprietary and proven combination of enzymes, herbal extracts, and trace minerals, the word AstraZyme® literally means “vehicle of energy”. Studies have shown this proprietary formula to dramatically enhance (by up to 66%!) the absorption of nutrients your body needs to function properly – including arginine, citrulline, tryptophan, folate, and glucosamine.

After water, your body is mostly made up of protein. In order for your body to effectively use the protein in the foods you eat, it must first be completely broken down from long-chain amino acids into peptides and single amino acids. These molecules then need to be efficiently absorbed to be of any value. AstraZyme enhances digestion by addressing both aspects of protein utilization needed for optimal health:

  1. The complete breakdown of protein
  2. Enhanced absorption of peptides and amino acids

The herbal extracts in AstraZyme come from two different plants: Panax notoginseng and Astragalus membranaceus. Both have been used for centuries and are well-known for their antioxidant and anti-inflammatory properties, as well as their ability to help strengthen the immune system. This specific herbal combination has been validated by science and demonstrated to enhance the cellular absorption of amino acids, vitamins, and glucose in both In vitro and In vivo studies.14

The third element of the AstraZyme formula is trace minerals. There are more than 5,000 enzymes in the human body with each enzyme dependent on a specific mineral to reach its full catalytic effect. AstraZyme includes 72 individual minerals demonstrated to have the most potent results.

Interestingly, this trace mineral complex also mirrors the same microscopic geometric pattern as those of the enzymes – tetrahedrons (four-sided pyramids) which act as a delivery system for the minerals. Once the “payload” of minerals has been delivered to the cell, this unique tetrahedron complex then uptakes various waste byproducts and helps safely pull them out of the body.

The particular type and source of mineral complex in AstraZyme enjoys a GRAS (generally recognized as safe) status in the supplement industry and is used in medical and pharmaceutical applications. Because of the purity and potency of the minerals, only very small doses are required.

The results achieved by the specific trio of enzymes, herbals, and trace minerals in AstraZyme are astounding and have been documented in a landmark clinical study. Some of the key findings include:15

● rate of absorption of peptides increased by 30%

● quantity of peptides absorbed increased by 41%

● rate of absorption of amino acids increased by more than 61%

● quantity of amino acids absorbed increased by 70%

By maximizing the digestion and absorption of proteins so they can be used to rebuild and refuel your body, you may experience increased energy, improved digestion, and better overall health and vitality.


Farm to Bottle Ingredients

The majority of daily vitamins and supplements on the market are made with synthetic ingredients, as well as fillers, binders, coloring, flavorings, preservatives, and other artificial ingredients that your body has a hard time recognizing. At Organixx, we’re proud to offer the absolute best nutritional formulas that help people get and stay healthy. Our products are made with REAL plants and whole FOODS that your body already knows how to assimilate and use to the greatest advantage for your health. They’ll help you look, feel, and live better... naturally!

People Over Profits

We believe in doing things differently. While most supplement companies spend the majority of their money on advertising, we spend ours on the highest-quality, clean, and non-GMO ingredients available – certified organic, whenever possible. In fact, we spend on average 400% (4 times) more to manufacture our products because of our certified organic ingredients and time-consuming fermentation and sprouting processes that increase bioavailability. In the end, you get exactly what you pay for – the best supplements on the market.

Maximum Nutrition

Many of our supplements and their ingredients are sprouted and/or fermented as part of the production process. You’ve likely heard about the gut health benefits of eating fermented foods. But did you know that fermentation also helps enhance the vitamin and mineral content of whatever’s being fermented? It’s a form of pre-digestion which means your body can absorb even more of the “good stuff” in the supplements.

More Bang for Your Buck

While our supplements might cost a little more, in the end, you save more. We focus on formulating synergistic BLENDS that address specific health needs. We start by researching the best and most effective synergistic combinations and then we source the cleanest, highest-quality ingredients available. You get the results you’re looking for without the expense and hassle of buying dozens of supplements and swallowing handfuls of pills every day. It’s a win-win for everyone.

Manufactured in the U.S.A.

All Organixx products are manufactured in the U.S.A. at an FDA-registered, CGMP-compliant facility. The vast majority of the individual whole food and specialty ingredients that we use in our supplements and skincare products are grown in and sourced right here in the U.S. The few ingredients sourced from other countries are indigenous to those regions, with ZERO of our ingredients being sourced from China.

Our Results Speak for Themselves

Over 115,000 health-conscious customers like you use and trust Organixx products to enhance their health and we’ve received well over 10,000 5-Star reviews. We also receive a LOT of overjoyed feedback from folks sharing how pleased they are to finally find a supplement company 100% committed to using the purest, non-GMO and certified organic ingredients wherever and whenever possible! Be sure to read our verified customer reviews for P3E here.


P3E Comparison Chart


Daily Usage

Daily Use

Take 3 capsules daily with each meal.

Capsules can also be opened and contents added to any* food or beverage (*not hot) and consumed immediately.

Advanced Use

Advanced Use

To accelerate healing or during times of increased stress, double or triple the dose for the first 90 days, then titrate down.

Also highly beneficial for repair & recovery when combined with fasting protocols.


Pairs Well With

If optimal digestive health is your priority, consider pairing with our powerful proteolytic probiotic that restores gut balance.
Shop Organixx ProBiotixx+

1-Year Money-Back Guarantee

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Enzymes are neither destroyed by the acid nor temperature in the digestive tract. By their nature, enzymes are designed to function in the stomach's extremely acidic conditions.
A majority of individuals with gastritis (inflammation of the stomach lining) have no problem taking P3E. However, there is a small population of people who may have a reaction. Therefore, it’s best to consult with your healthcare provider before taking P3E, especially if you have any pre-existing health conditions such as gastritis.
Yes. We only use natural ingredients in P3E that contain no animal agents and are suitable for those on both vegetarian and vegan diets. In addition, P3E contains no GMOs, chemical fillers, or binders.
Please consult with your physician before giving any supplements to children.

If your doctor is in agreement, we suggest a daily dose of one (1) capsule for every 20 kg (44 lbs) of body weight.
P3E was formulated for humans. However, we recommend consulting with your veterinarian to determine what enzymes your fur babies may need as this could be a good fit for them.
For all Organixx products, we use only the cleanest and purest ingredients available. Any individual ingredients that are certified organic are specified on the label.

In the case of P3E, enzymes are a special situation and cannot be certified organic because they don't grow from a seed in the ground.
We use stabilized hypoallergenic rice bran as an agent to prolong the shelf life of the enzymes which can become activated by moisture. In this way we’re able to offer longer shelf life and improve the effectiveness of the product.
Yes, P3E capsules contain a powder that can be added to any beverage or sprinkled on food and consumed that way if preferred. However, as the enzymes are activated by moisture, it’s best to consume immediately once opened. It’s also best not to add to hot foods or beverages to avoid any potential heat damage to the enzymes.
OrganiZymes was a digestive enzyme formula containing 17 different essential enzymes for supporting proper digestion.

P3E is a superior formula. In addition to an advanced digestive enzyme blend, it contains 5 different kinds of powerful protease enzymes. These proteases break down all types of protein (both plant and animal) for improved digestion and overall health.
We offer free shipping on all domestic (U.S.) Subscribe & Save orders, regardless of the order value. All other domestic orders of $99+ receive free shipping. Canadian residents can get free shipping for all orders of $149+ and international customers receive free shipping on all orders of $199 or more.
Subscribe & Save is available on every product and is the best choice for products you intend to use daily. Not only do you get an automatic savings of at least 15% off*, but you also don’t have to worry about remembering to order your favorite supplements month after month. (*Tip: 3- and 6-bottle Subscribe & Save options enjoy even greater savings.) Click here to get all the details about our Subscribe & Save program.
We ship 7 days per week. Orders received by 9am Eastern time will likely ship the same day while all other orders will likely ship out the next business day. Subject to change based on volume.
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Customer Reviews

Based on 49 reviews

I take it before eating nonveg(meat) which helps me to digest it without discomfort

Excellent Product!

I love this new enzyme formula. I highly recommend it for anyone who has gut issues like myself. Best product on the market! Thanks Organix.


Can’t tell a difference so far.


Simply excellent product!

It does the job!

Had never taken digestive enzymes. From first use of this product, things seemed better and whenever you can get a little help digestion wise the benefits cascade. Don’t take with every meal but just with those whole food, plant-based, high fiber foods that can be hard to digest at my age of 70. Keep it pure guys … that’s what we count on.

A must have

This is a very good and powerful product, helps a lot the digestion.

Good help

As a cancer survivor with altered digestion, Enzyme 17 enzymes help with my digestion. It seems to help lessen reflux which I need to avoid.

Great Enzymes

I can't always remember at every meal but if I take three at night before bed it keeps me regular. Thank you!


Enzyme 17

Mild !!

Because I can’t swallow pills, I open the capsules and empty in my mouth. This enzyme powder does not burn the mouth.
Now, as for digestive help, my health is so precarious I can’t perceive yet the benefits.

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